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KMID : 0941820110210040390
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Korean Journal of Clinical Pharmacy
2011 Volume.21 No. 4 p.390 ~ p.393
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Oxaliplatin Induced Angioedema in a Rectal Cancer Patient : A Clinical Case Report
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Noh Mi-Hee
Lee Yu-Jeong
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Abstract
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We report an unusual case of angioedema induced by intravenous oxaliplatin in a patient with rectal cancer. Intravenous oxaliplatin was administered to the patient according to FOLFOX regimen (oxaliplatin/leucovorin/5-fluorouracil) for the management of his colorectal carcinoma. The patient had been on FOLFOX regimen for several months without reporting any adverse effects, but he experienced angioedema suddenly during his 9th cycle of chemotherapy. Angioedema was observed about 2 hours after the initiation of oxaliplatin infusion. Oxaliplatin was stopped then the patient became stable. This case report demonstrates that intravenous oxaliplatin may induce angioedema several hours after the initiation of oxaliplatin infusion in later cycles of chemotherapy.
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KEYWORD
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oxaliplatin, angioedema, hypersensitivity, case study
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